Billable / Specific Code
ICD-10-CM Z17.421 is the diagnosis code for Hormone receptor negative with human epidermal growth factor receptor 2 negative status. This code falls under the section "Estrogen, and other hormones and factors receptor status" within Chapter 21 — Factors influencing health status and contact with health services (Z00-Z99). It is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. Medical coders and healthcare providers use this code to document and classify diagnoses in electronic health records, insurance claims, and clinical databases.
Understanding where Z17.421 sits in the ICD-10-CM classification helps ensure proper coding:
Yes, Z17.421 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
Z17.421 is the ICD-10-CM diagnosis code for "Hormone receptor negative with human epidermal growth factor receptor 2 negative status". It is used by healthcare providers to classify and document this condition in medical records and insurance claims.
The parent code of Z17.421 is Z17.42 ("Hormone receptor negative"). Z17.421 provides a more specific classification within this category.
Z17.421 is located in Section Z17 — "Estrogen, and other hormones and factors receptor status" within Chapter 21 of the ICD-10-CM Tabular List.
Use Z17.421 when the patients documented diagnosis matches "Hormone receptor negative with human epidermal growth factor receptor 2 negative status" and the clinical documentation supports this level of specificity. Always verify with the latest ICD-10-CM guidelines and payer requirements.
The ICD-10-CM code for Hormone receptor negative with human epidermal growth factor receptor 2 negative status is Z17.421.
Yes, Z17.421 can be used as a primary diagnosis code since it is billable and specific.
Z17.421 is in Chapter 21 of the ICD-10-CM Tabular List.
Yes, Z17.421 is a valid ICD-10-CM code for the 2026 fiscal year, subject to official CMS updates.