E88
Non-Billable

Other and unspecified metabolic disorders

Non-Billable / Non-Specific Code

What is Other and unspecified metabolic disorders?

ICD-10-CM E88 is the diagnosis code for Other and unspecified metabolic disorders. This code falls under the section "Metabolic disorders" within Chapter 4 — Endocrine, nutritional and metabolic diseases (E00-E89). It is a non-billable/non-specific ICD-10-CM code that should not be used for reimbursement. A more specific sub-code is required for billing. Medical coders and healthcare providers use this code to document and classify diagnoses in electronic health records, insurance claims, and clinical databases.

⛔ Excludes1

Coding Guidelines for E88

⛔ Type 1 Excludes (Never code together)

The following conditions should never be coded at the same time as E88. They are mutually exclusive:

  • histiocytosis X (chronic) (C96.6)

ICD-10-CM Code Hierarchy

Understanding where E88 sits in the ICD-10-CM classification helps ensure proper coding:

Current CodeE88 — Other and unspecified metabolic disorders
Sub-Codes 8 entries
E88.0Disorders of plasma-protein metabolism, not elsewhere classifiedNon-BillableE88.01Alpha-1-antitrypsin deficiencyBillableE88.02Plasminogen deficiencyBillableE88.09Other disorders of plasma-protein metabolism, not elsewhere classifiedBillableE88.1Lipodystrophy, not elsewhere classifiedNon-BillableE88.10Lipodystrophy, unspecifiedBillableE88.11Partial lipodystrophyBillableE88.12Generalized lipodystrophyBillableE88.13Localized lipodystrophyBillableE88.14HIV-associated lipodystrophyBillableE88.19Other lipodystrophy, not elsewhere classifiedBillableE88.2Lipomatosis, not elsewhere classifiedBillableE88.3Tumor lysis syndromeBillableE88.4Mitochondrial metabolism disordersNon-BillableE88.40Mitochondrial metabolism disorder, unspecifiedBillableE88.41MELAS syndromeBillableE88.42MERRF syndromeBillableE88.43Disorders of mitochondrial tRNA synthetasesBillableE88.49Other mitochondrial metabolism disordersBillableE88.8Other specified metabolic disordersNon-BillableE88.81Metabolic syndrome and other insulin resistanceNon-BillableE88.810Metabolic syndromeBillableE88.811Insulin resistance syndrome, Type ABillableE88.818Other insulin resistanceBillableE88.819Insulin resistance, unspecifiedBillableE88.82Obesity due to disruption of MC4R pathwayBillableE88.89Other specified metabolic disordersBillableE88.9Metabolic disorder, unspecifiedBillableE88.AWasting disease (syndrome) due to underlying conditionBillable
Related Codes

Frequently Asked Questions

Is E88 a billable ICD-10-CM code?

No, E88 is a non-billable/non-specific code. You should use a more specific sub-code for billing and reimbursement.

What does E88 mean?

E88 is the ICD-10-CM diagnosis code for "Other and unspecified metabolic disorders". It is used by healthcare providers to classify and document this condition in medical records and insurance claims.

What section is E88 in?

E88 is located in Section E70-E88 — "Metabolic disorders" within Chapter 4 of the ICD-10-CM Tabular List.

What are the sub-codes of E88?

E88 has 8 sub-code(s) that provide more specific detail: E88.0, E88.1, E88.2, E88.3, E88.4 and more.

When should I use E88?

Use E88 when the patients documented diagnosis matches "Other and unspecified metabolic disorders" and the clinical documentation supports this level of specificity. Always verify with the latest ICD-10-CM guidelines and payer requirements.

People Also Ask

What is the ICD-10 code for Other and unspecified metabolic disorders?

The ICD-10-CM code for Other and unspecified metabolic disorders is E88.

Can E88 be used for primary diagnosis?

No, E88 is non-billable. Use a more specific sub-code for primary diagnosis billing.

What chapter is E88 in?

E88 is in Chapter 4 of the ICD-10-CM Tabular List.

What conditions are excluded from E88?

Type 1 Excludes for E88 include: histiocytosis X (chronic) (C96.6).

Is E88 valid for 2026?

Yes, E88 is a valid ICD-10-CM code for the 2026 fiscal year, subject to official CMS updates.

See Also

← PreviousE87.8Other disorders of electrolyte and fluid balance, not elsewhere classifiedNext →E88.0Disorders of plasma-protein metabolism, not elsewhere classified
Code Details
E88
Other and unspecified metabolic disorders
Non-Billable / Non-Specific Code
4 — Endocrine, nutritional and metabolic diseases (E00-E89)
E70-E88 — Metabolic disorders
2026 ICD-10-CM