Non-Billable / Non-Specific Code
ICD-10-CM R65.1 is the diagnosis code for Systemic inflammatory response syndrome (SIRS) of non-infectious origin. This code falls under the section "General symptoms and signs" within Chapter 18 — Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R99). It is a non-billable/non-specific ICD-10-CM code that should not be used for reimbursement. A more specific sub-code is required for billing. Medical coders and healthcare providers use this code to document and classify diagnoses in electronic health records, insurance claims, and clinical databases.
The following conditions should never be coded at the same time as R65.1. They are mutually exclusive:
Understanding where R65.1 sits in the ICD-10-CM classification helps ensure proper coding:
No, R65.1 is a non-billable/non-specific code. You should use a more specific sub-code for billing and reimbursement.
R65.1 is the ICD-10-CM diagnosis code for "Systemic inflammatory response syndrome (SIRS) of non-infectious origin". It is used by healthcare providers to classify and document this condition in medical records and insurance claims.
The parent code of R65.1 is R65 ("Symptoms and signs specifically associated with systemic inflammation and infection"). R65.1 provides a more specific classification within this category.
R65.1 is located in Section R50-R69 — "General symptoms and signs" within Chapter 18 of the ICD-10-CM Tabular List.
R65.1 has 2 sub-code(s) that provide more specific detail: R65.10, R65.11.
Use R65.1 when the patients documented diagnosis matches "Systemic inflammatory response syndrome (SIRS) of non-infectious origin" and the clinical documentation supports this level of specificity. Always verify with the latest ICD-10-CM guidelines and payer requirements.
The ICD-10-CM code for Systemic inflammatory response syndrome (SIRS) of non-infectious origin is R65.1.
No, R65.1 is non-billable. Use a more specific sub-code for primary diagnosis billing.
R65.1 is in Chapter 18 of the ICD-10-CM Tabular List.
Type 1 Excludes for R65.1 include: sepsis- code to infection; severe sepsis (R65.2).
Yes, R65.1 is a valid ICD-10-CM code for the 2026 fiscal year, subject to official CMS updates.