Non-Billable / Non-Specific Code
ICD-10-CM Z16 is the diagnosis code for Resistance to antimicrobial drugs. This code falls under the section "Resistance to antimicrobial drugs" within Chapter 21 — Factors influencing health status and contact with health services (Z00-Z99). It is a non-billable/non-specific ICD-10-CM code that should not be used for reimbursement. A more specific sub-code is required for billing. Medical coders and healthcare providers use this code to document and classify diagnoses in electronic health records, insurance claims, and clinical databases.
The following conditions should never be coded at the same time as Z16. They are mutually exclusive:
Understanding where Z16 sits in the ICD-10-CM classification helps ensure proper coding:
No, Z16 is a non-billable/non-specific code. You should use a more specific sub-code for billing and reimbursement.
Z16 is the ICD-10-CM diagnosis code for "Resistance to antimicrobial drugs". It is used by healthcare providers to classify and document this condition in medical records and insurance claims.
Z16 is located in Section Z16 — "Resistance to antimicrobial drugs" within Chapter 21 of the ICD-10-CM Tabular List.
Z16 has 3 sub-code(s) that provide more specific detail: Z16.1, Z16.2, Z16.3.
Use Z16 when the patients documented diagnosis matches "Resistance to antimicrobial drugs" and the clinical documentation supports this level of specificity. Always verify with the latest ICD-10-CM guidelines and payer requirements.
The ICD-10-CM code for Resistance to antimicrobial drugs is Z16.
No, Z16 is non-billable. Use a more specific sub-code for primary diagnosis billing.
Z16 is in Chapter 21 of the ICD-10-CM Tabular List.
Type 1 Excludes for Z16 include: Methicillin resistant Staphylococcus aureus infection (A49.02); Methicillin resistant Staphylococcus aureus pneumonia (J15.212); Sepsis due to Methicillin resistant Staphylococcus aureus (A41.02).
Yes, Z16 is a valid ICD-10-CM code for the 2026 fiscal year, subject to official CMS updates.