D57
Non-Billable

Sickle-cell disorders

Non-Billable / Non-Specific Code

What is Sickle-cell disorders?

ICD-10-CM D57 is the diagnosis code for Sickle-cell disorders. This code falls under the section "Hemolytic anemias" within Chapter 3 — Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89). It is a non-billable/non-specific ICD-10-CM code that should not be used for reimbursement. A more specific sub-code is required for billing. Medical coders and healthcare providers use this code to document and classify diagnoses in electronic health records, insurance claims, and clinical databases.

⛔ Excludes1

Coding Guidelines for D57

⛔ Type 1 Excludes (Never code together)

The following conditions should never be coded at the same time as D57. They are mutually exclusive:

  • other hemoglobinopathies (D58.-)

ICD-10-CM Code Hierarchy

Understanding where D57 sits in the ICD-10-CM classification helps ensure proper coding:

Sub-Codes 6 entries
D57.0Hb-SS disease with crisisNon-BillableD57.00Hb-SS disease with crisis, unspecifiedBillableD57.01Hb-SS disease with acute chest syndromeBillableD57.02Hb-SS disease with splenic sequestrationBillableD57.03Hb-SS disease with cerebral vascular involvementBillableD57.04Hb-SS disease with dactylitisBillableD57.09Hb-SS disease with crisis with other specified complicationBillableD57.1Sickle-cell disease without crisisBillableD57.2Sickle-cell/Hb-C diseaseNon-BillableD57.20Sickle-cell/Hb-C disease without crisisBillableD57.21Sickle-cell/Hb-C disease with crisisNon-BillableD57.211Sickle-cell/Hb-C disease with acute chest syndromeBillableD57.212Sickle-cell/Hb-C disease with splenic sequestrationBillableD57.213Sickle-cell/Hb-C disease with cerebral vascular involvementBillableD57.214Sickle-cell/Hb-C disease with dactylitisBillableD57.218Sickle-cell/Hb-C disease with crisis with other specified complicationBillableD57.219Sickle-cell/Hb-C disease with crisis, unspecifiedBillableD57.3Sickle-cell traitBillableD57.4Sickle-cell thalassemiaNon-BillableD57.40Sickle-cell thalassemia without crisisBillableD57.41Sickle-cell thalassemia, unspecified, with crisisNon-BillableD57.411Sickle-cell thalassemia, unspecified, with acute chest syndromeBillableD57.412Sickle-cell thalassemia, unspecified, with splenic sequestrationBillableD57.413Sickle-cell thalassemia, unspecified, with cerebral vascular involvementBillableD57.414Sickle-cell thalassemia, unspecified, with dactylitisBillableD57.418Sickle-cell thalassemia, unspecified, with crisis with other specified complicationBillableD57.419Sickle-cell thalassemia, unspecified, with crisisBillableD57.42Sickle-cell thalassemia beta zero without crisisBillableD57.43Sickle-cell thalassemia beta zero with crisisNon-BillableD57.431Sickle-cell thalassemia beta zero with acute chest syndromeBillableD57.432Sickle-cell thalassemia beta zero with splenic sequestrationBillableD57.433Sickle-cell thalassemia beta zero with cerebral vascular involvementBillableD57.434Sickle-cell thalassemia beta zero with dactylitisBillableD57.438Sickle-cell thalassemia beta zero with crisis with other specified complicationBillableD57.439Sickle-cell thalassemia beta zero with crisis, unspecifiedBillableD57.44Sickle-cell thalassemia beta plus without crisisBillableD57.45Sickle-cell thalassemia beta plus with crisisNon-BillableD57.451Sickle-cell thalassemia beta plus with acute chest syndromeBillableD57.452Sickle-cell thalassemia beta plus with splenic sequestrationBillableD57.453Sickle-cell thalassemia beta plus with cerebral vascular involvementBillableD57.454Sickle-cell thalassemia beta plus with dactylitisBillableD57.458Sickle-cell thalassemia beta plus with crisis with other specified complicationBillableD57.459Sickle-cell thalassemia beta plus with crisis, unspecifiedBillableD57.8Other sickle-cell disordersNon-BillableD57.80Other sickle-cell disorders without crisisBillableD57.81Other sickle-cell disorders with crisisNon-BillableD57.811Other sickle-cell disorders with acute chest syndromeBillableD57.812Other sickle-cell disorders with splenic sequestrationBillableD57.813Other sickle-cell disorders with cerebral vascular involvementBillableD57.814Other sickle-cell disorders with dactylitisBillableD57.818Other sickle-cell disorders with crisis with other specified complicationBillableD57.819Other sickle-cell disorders with crisis, unspecifiedBillable
Related Codes

Frequently Asked Questions

Is D57 a billable ICD-10-CM code?

No, D57 is a non-billable/non-specific code. You should use a more specific sub-code for billing and reimbursement.

What does D57 mean?

D57 is the ICD-10-CM diagnosis code for "Sickle-cell disorders". It is used by healthcare providers to classify and document this condition in medical records and insurance claims.

What section is D57 in?

D57 is located in Section D55-D59 — "Hemolytic anemias" within Chapter 3 of the ICD-10-CM Tabular List.

What are the sub-codes of D57?

D57 has 6 sub-code(s) that provide more specific detail: D57.0, D57.1, D57.2, D57.3, D57.4 and more.

When should I use D57?

Use D57 when the patients documented diagnosis matches "Sickle-cell disorders" and the clinical documentation supports this level of specificity. Always verify with the latest ICD-10-CM guidelines and payer requirements.

People Also Ask

What is the ICD-10 code for Sickle-cell disorders?

The ICD-10-CM code for Sickle-cell disorders is D57.

Can D57 be used for primary diagnosis?

No, D57 is non-billable. Use a more specific sub-code for primary diagnosis billing.

What chapter is D57 in?

D57 is in Chapter 3 of the ICD-10-CM Tabular List.

What conditions are excluded from D57?

Type 1 Excludes for D57 include: other hemoglobinopathies (D58.-).

Is D57 valid for 2026?

Yes, D57 is a valid ICD-10-CM code for the 2026 fiscal year, subject to official CMS updates.

See Also

← PreviousD56.9Thalassemia, unspecifiedNext →D57.0Hb-SS disease with crisis
Code Details
D57
Sickle-cell disorders
Non-Billable / Non-Specific Code
3 — Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)
D55-D59 — Hemolytic anemias
2026 ICD-10-CM