Non-Billable / Non-Specific Code
ICD-10-CM E88.0 is the diagnosis code for Disorders of plasma-protein metabolism, not elsewhere classified. This code falls under the section "Metabolic disorders" within Chapter 4 — Endocrine, nutritional and metabolic diseases (E00-E89). It is a non-billable/non-specific ICD-10-CM code that should not be used for reimbursement. A more specific sub-code is required for billing. Medical coders and healthcare providers use this code to document and classify diagnoses in electronic health records, insurance claims, and clinical databases.
The following conditions should never be coded at the same time as E88.0. They are mutually exclusive:
The following conditions are not included in E88.0. If the patient has both, code each condition separately:
Understanding where E88.0 sits in the ICD-10-CM classification helps ensure proper coding:
No, E88.0 is a non-billable/non-specific code. You should use a more specific sub-code for billing and reimbursement.
E88.0 is the ICD-10-CM diagnosis code for "Disorders of plasma-protein metabolism, not elsewhere classified". It is used by healthcare providers to classify and document this condition in medical records and insurance claims.
The parent code of E88.0 is E88 ("Other and unspecified metabolic disorders"). E88.0 provides a more specific classification within this category.
E88.0 is located in Section E70-E88 — "Metabolic disorders" within Chapter 4 of the ICD-10-CM Tabular List.
E88.0 has 3 sub-code(s) that provide more specific detail: E88.01, E88.02, E88.09.
Use E88.0 when the patients documented diagnosis matches "Disorders of plasma-protein metabolism, not elsewhere classified" and the clinical documentation supports this level of specificity. Always verify with the latest ICD-10-CM guidelines and payer requirements.
The ICD-10-CM code for Disorders of plasma-protein metabolism, not elsewhere classified is E88.0.
No, E88.0 is non-billable. Use a more specific sub-code for primary diagnosis billing.
E88.0 is in Chapter 4 of the ICD-10-CM Tabular List.
Type 1 Excludes for E88.0 include: monoclonal gammopathy (of undetermined significance) (D47.2); polyclonal hypergammaglobulinemia (D89.0); Waldenström macroglobulinemia (C88.00).
Yes, E88.0 is a valid ICD-10-CM code for the 2026 fiscal year, subject to official CMS updates.