D81.8
Non-Billable

Other combined immunodeficiencies

Non-Billable / Non-Specific Code

What is Other combined immunodeficiencies?

ICD-10-CM D81.8 is the diagnosis code for Other combined immunodeficiencies. This code falls under the section "Certain disorders involving the immune mechanism" within Chapter 3 — Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89). It is a non-billable/non-specific ICD-10-CM code that should not be used for reimbursement. A more specific sub-code is required for billing. Medical coders and healthcare providers use this code to document and classify diagnoses in electronic health records, insurance claims, and clinical databases.

Coding Guidelines for D81.8

Always refer to the official ICD-10-CM Tabular List for complete coding guidelines. Ensure documentation supports the specificity of the code selected. When in doubt, consult a certified medical coder or the latest CMS guidelines.

ICD-10-CM Code Hierarchy

Understanding where D81.8 sits in the ICD-10-CM classification helps ensure proper coding:

Sub-Codes 3 entries
D81.81Biotin-dependent carboxylase deficiencyNon-BillableD81.810Biotinidase deficiencyBillableD81.818Other biotin-dependent carboxylase deficiencyBillableD81.819Biotin-dependent carboxylase deficiency, unspecifiedBillableD81.82Activated Phosphoinositide 3-kinase Delta Syndrome [APDS]BillableD81.89Other combined immunodeficienciesBillable
Related Codes

Frequently Asked Questions

Is D81.8 a billable ICD-10-CM code?

No, D81.8 is a non-billable/non-specific code. You should use a more specific sub-code for billing and reimbursement.

What does D81.8 mean?

D81.8 is the ICD-10-CM diagnosis code for "Other combined immunodeficiencies". It is used by healthcare providers to classify and document this condition in medical records and insurance claims.

What is the parent code of D81.8?

The parent code of D81.8 is D81 ("Combined immunodeficiencies"). D81.8 provides a more specific classification within this category.

What section is D81.8 in?

D81.8 is located in Section D80-D89 — "Certain disorders involving the immune mechanism" within Chapter 3 of the ICD-10-CM Tabular List.

What are the sub-codes of D81.8?

D81.8 has 3 sub-code(s) that provide more specific detail: D81.81, D81.82, D81.89.

When should I use D81.8?

Use D81.8 when the patients documented diagnosis matches "Other combined immunodeficiencies" and the clinical documentation supports this level of specificity. Always verify with the latest ICD-10-CM guidelines and payer requirements.

People Also Ask

What is the ICD-10 code for Other combined immunodeficiencies?

The ICD-10-CM code for Other combined immunodeficiencies is D81.8.

Can D81.8 be used for primary diagnosis?

No, D81.8 is non-billable. Use a more specific sub-code for primary diagnosis billing.

What chapter is D81.8 in?

D81.8 is in Chapter 3 of the ICD-10-CM Tabular List.

Is D81.8 valid for 2026?

Yes, D81.8 is a valid ICD-10-CM code for the 2026 fiscal year, subject to official CMS updates.

See Also

← PreviousD81.7Major histocompatibility complex class II deficiencyNext →D81.81Biotin-dependent carboxylase deficiency
Code Details
D81.8
Other combined immunodeficiencies
Non-Billable / Non-Specific Code
3 — Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)
D80-D89 — Certain disorders involving the immune mechanism
2026 ICD-10-CM