Non-Billable / Non-Specific Code
ICD-10-CM D81 is the diagnosis code for Combined immunodeficiencies. This code falls under the section "Certain disorders involving the immune mechanism" within Chapter 3 — Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89). It is a non-billable/non-specific ICD-10-CM code that should not be used for reimbursement. A more specific sub-code is required for billing. Medical coders and healthcare providers use this code to document and classify diagnoses in electronic health records, insurance claims, and clinical databases.
The following conditions should never be coded at the same time as D81. They are mutually exclusive:
Understanding where D81 sits in the ICD-10-CM classification helps ensure proper coding:
No, D81 is a non-billable/non-specific code. You should use a more specific sub-code for billing and reimbursement.
D81 is the ICD-10-CM diagnosis code for "Combined immunodeficiencies". It is used by healthcare providers to classify and document this condition in medical records and insurance claims.
D81 is located in Section D80-D89 — "Certain disorders involving the immune mechanism" within Chapter 3 of the ICD-10-CM Tabular List.
D81 has 10 sub-code(s) that provide more specific detail: D81.0, D81.1, D81.2, D81.3, D81.4 and more.
Use D81 when the patients documented diagnosis matches "Combined immunodeficiencies" and the clinical documentation supports this level of specificity. Always verify with the latest ICD-10-CM guidelines and payer requirements.
The ICD-10-CM code for Combined immunodeficiencies is D81.
No, D81 is non-billable. Use a more specific sub-code for primary diagnosis billing.
D81 is in Chapter 3 of the ICD-10-CM Tabular List.
Type 1 Excludes for D81 include: autosomal recessive agammaglobulinemia (Swiss type) (D80.0).
Yes, D81 is a valid ICD-10-CM code for the 2026 fiscal year, subject to official CMS updates.