D89
Non-Billable

Other disorders involving the immune mechanism, not elsewhere classified

Non-Billable / Non-Specific Code

What is Other disorders involving the immune mechanism, not elsewhere classified?

ICD-10-CM D89 is the diagnosis code for Other disorders involving the immune mechanism, not elsewhere classified. This code falls under the section "Certain disorders involving the immune mechanism" within Chapter 3 — Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89). It is a non-billable/non-specific ICD-10-CM code that should not be used for reimbursement. A more specific sub-code is required for billing. Medical coders and healthcare providers use this code to document and classify diagnoses in electronic health records, insurance claims, and clinical databases.

⛔ Excludes1
â„šī¸ Excludes2

Coding Guidelines for D89

⛔ Type 1 Excludes (Never code together)

The following conditions should never be coded at the same time as D89. They are mutually exclusive:

  • hyperglobulinemia NOS (R77.1)
  • monoclonal gammopathy (of undetermined significance) (D47.2)

â„šī¸ Type 2 Excludes (Code separately if applicable)

The following conditions are not included in D89. If the patient has both, code each condition separately:

  • transplant failure and rejection (T86.-)

ICD-10-CM Code Hierarchy

Understanding where D89 sits in the ICD-10-CM classification helps ensure proper coding:

Sub-Codes 7 entries
D89.0Polyclonal hypergammaglobulinemiaBillableD89.1CryoglobulinemiaBillableD89.2Hypergammaglobulinemia, unspecifiedBillableD89.3Immune reconstitution syndromeBillableD89.4Mast cell activation syndrome and related disordersNon-BillableD89.40Mast cell activation, unspecifiedBillableD89.41Monoclonal mast cell activation syndromeBillableD89.42Idiopathic mast cell activation syndromeBillableD89.43Secondary mast cell activationBillableD89.44Hereditary alpha tryptasemiaBillableD89.49Other mast cell activation disorderBillableD89.8Other specified disorders involving the immune mechanism, not elsewhere classifiedNon-BillableD89.81Graft-versus-host diseaseNon-BillableD89.810Acute graft-versus-host diseaseBillableD89.811Chronic graft-versus-host diseaseBillableD89.812Acute on chronic graft-versus-host diseaseBillableD89.813Graft-versus-host disease, unspecifiedBillableD89.82Autoimmune lymphoproliferative syndrome [ALPS]BillableD89.83Cytokine release syndromeNon-BillableD89.831Cytokine release syndrome, grade 1BillableD89.832Cytokine release syndrome, grade 2BillableD89.833Cytokine release syndrome, grade 3BillableD89.834Cytokine release syndrome, grade 4BillableD89.835Cytokine release syndrome, grade 5BillableD89.839Cytokine release syndrome, grade unspecifiedBillableD89.84IgG4-related diseaseBillableD89.89Other specified disorders involving the immune mechanism, not elsewhere classifiedBillableD89.9Disorder involving the immune mechanism, unspecifiedBillable
Related Codes

Frequently Asked Questions

Is D89 a billable ICD-10-CM code?

No, D89 is a non-billable/non-specific code. You should use a more specific sub-code for billing and reimbursement.

What does D89 mean?

D89 is the ICD-10-CM diagnosis code for "Other disorders involving the immune mechanism, not elsewhere classified". It is used by healthcare providers to classify and document this condition in medical records and insurance claims.

What section is D89 in?

D89 is located in Section D80-D89 — "Certain disorders involving the immune mechanism" within Chapter 3 of the ICD-10-CM Tabular List.

What are the sub-codes of D89?

D89 has 7 sub-code(s) that provide more specific detail: D89.0, D89.1, D89.2, D89.3, D89.4 and more.

When should I use D89?

Use D89 when the patients documented diagnosis matches "Other disorders involving the immune mechanism, not elsewhere classified" and the clinical documentation supports this level of specificity. Always verify with the latest ICD-10-CM guidelines and payer requirements.

People Also Ask

What is the ICD-10 code for Other disorders involving the immune mechanism, not elsewhere classified?

The ICD-10-CM code for Other disorders involving the immune mechanism, not elsewhere classified is D89.

Can D89 be used for primary diagnosis?

No, D89 is non-billable. Use a more specific sub-code for primary diagnosis billing.

What chapter is D89 in?

D89 is in Chapter 3 of the ICD-10-CM Tabular List.

What conditions are excluded from D89?

Type 1 Excludes for D89 include: hyperglobulinemia NOS (R77.1); monoclonal gammopathy (of undetermined significance) (D47.2).

Is D89 valid for 2026?

Yes, D89 is a valid ICD-10-CM code for the 2026 fiscal year, subject to official CMS updates.

See Also

← PreviousD86.9Sarcoidosis, unspecifiedNext →D89.0Polyclonal hypergammaglobulinemia
Code Details
D89
Other disorders involving the immune mechanism, not elsewhere classified
Non-Billable / Non-Specific Code
3 — Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)
D80-D89 — Certain disorders involving the immune mechanism
2026 ICD-10-CM